Suppressed/Low-level Viral Load Testing
GenoSure Archive is the newest suppression management offering by Monogram Biosciences. GenoSure Archive is designed to provide HIV-1 antiretroviral (ARV) drug resistance data when standard resistance testing cannot be performed due to inadequate plasma viral load. The assay exploits peripheral blood mononuclear cells (PBMCs) in whole blood to interrogate the viral archive and uses next-generation sequencing (NGS) methods to provide a list of the archived mutations; then it assigns susceptibility calls of "sensitive", "resistant", or "resistance possible" based on those mutations. GenoSure Archive provides valuable information for nucleoside reverse transcriptase inhibitors (NRTIs), nonnucleoside reverse transcriptase inhibitors (NNRTIs), integrase inhibitors (INIs), and protease inhibitors (PIs) when regimen switches are being considered.
The Trofile DNA Co-Receptor Tropism Assay applies the proven performance of Trofile to cell-associated viral DNA. For patients with undetectable viral loads, Trofile DNA can be considered when a patient’s viral tropism is unknown and substitution with a CCR5 antagonist is desired. Unlike the standard Trofile assay, which uses viral RNA found in the plasma of patients with viral loads ≥ 1000 copies/mL, Trofile DNA uses viral DNA extracted from cells in a whole blood draw