Trofile® is a phenotypic viral RNA assay that is the only commercially available tropism assay that has been clinically validated through use in Phase 2 and Phase 3 clinical studies to identify CCR5 antagonist candidates.1-3 One such drug, maraviroc, is available for clinical use. Trofile is a clinically validated assay for the selection of clinically appropriate patients for maraviroc. Click here to view a sample report.
The Trofile Coreceptor Tropism Assay:
- Is 100% sensitive at detecting 0.3% CXR4-using minor variant.4
- Uses the complete gp160 coding region of the HIV-1 envelope protein to ensure that all determinants of tropism are tested.
- Can successfully amplify and reliably report results with viral loads ≥1,000 copies/mL.
Trofile has been shown to be accurate, precise, sensitive, reproducible, and robust in the measurement of HIV-1 co-receptor tropism. More than 23,000 samples have been tested using this assay.