Interleukin 28B (IL28B) Polymorphism Testing

Interleukin 28B Polymorphism

A single nucleotide polymorphism (SNP) located near the interleukin 28B (IL28B) gene on chromosome 19 has been found to be associated with early viral response and improved sustained treatment response of hepatitis C virus (HCV) genotype 1 infection to pegylated Interferon plus ribivirin therapy.1,2 The favorable genotype is more common in individuals of European ancestry (37%) as compared to African Americans (14%) and Hispanics (29%), thus potentially explaining some of the observed differences in treatment response between racial groups.2 Performing an IL28B polymorphism test can add one more piece of information that may help determine how and when to treat a patient with hepatitis C.