Through its patient and clinical trial testing, Monogram has built an extensive library of viruses from which it has generated robust resistance characterization data that are available to Pharma clients.

Clients can query Monogram's database to ask questions about prevalence of mutational patterns, genotypic/phenotypic correlates (by specific mutational pattern), as well as Replication Capacity (RC). These data can be useful not only in early stage drug development efforts, but in post-marketing efforts as well.

Monogram's database contains the following:
Phenotypes: 216,000
Genotypes: 106,000
Matched Phenotypes and Genotypes: 120,000+

Below are links to posters and presentations that include data from Monogram database queries. If you would like to learn more about the utility of these types of queries, please contact us.

Click on the titles below to download posters featuring clinical studies where the Monogram database was utilized:

• Prediction of NRTI options by linking reverse transcriptase genotype to phenotype breakpoints
• Decreased replication capacity of HIV-1 clinical isolates containing K65R or M184V RT mutations
• Atazanavir (ATV) resistance in a protease inhibitor naive patient treated with ATV/ritonavir associated with development of high-level ATV resistance and the N88S mutation in protease
• A comparison of the phenotypic profiles of emtricitabine (FTC) and lamivudine (3TC)
• Differences in enhanced susceptibilities to NNRTIs and to zidovudine (ZDV) in site directed mutants (SDMs) bearing K65R, L74V, or M184V
• Comparison of phenotypic effects of NRTI mutations on emtricitabine (FTC) and lamivudine (3TC)
• Characterization of patient-derived HIV-1 isolates containing the L74V or K65R mutations in reverse transcriptase (RT)
• HIV clinical isolates containing mutations representative of those selected after first line failure with unboosted GW433908 remain sensitive to other protease inhibitors
• Impact of residue 50 substitutions on phenotypic susceptibility to protease inhibitors
• Cross-resistance of clinical samples with K65R, L74V, and M184V mutations

For more information on Monogram assays, services and pricing, please contact us.