PhenoSense GT is a resistance test that combines three tests, PhenoSense^® HIV, GeneSeq^® HIV and Replication Capacity (RC) to make up one complete picture of drug resistance. The combination test is performed from the same blood sample and is reported on one report form. PhenoSense GT looks at an individual's HIV using two different methodologies, so that the most effective treatment can be selected. It is a direct measure of the virus' ability to replicate in given concentrations of antiviral compounds as measured by the phenotypic portion of PhenoSense GT. The patient virus is also sequenced, with the genotypic data provided alongside the susceptibility results. Finally, it measures the inherent ability of the virus to make copies of itself - known as replication capacity, one component of viral fitness. PhenoSense GT uses advanced technology and offers consistent and clear results because both phenotypic and genotypic results come from the same blood sample, and some of the discrepancies between phenotypic measurements and genotypic predictions are resolved as part of the assay.

The report form includes both phenotypic and genotypic drug resistance information for all of the approved nucleoside reverse transcriptase inhibitors (NRTIs), non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs).

Features and benefits of PhenoSense GT assay:

• Combines the most advanced phenotypic test (PhenoSense HIV) with the most advanced genotypic test (GeneSeq HIV)
• Provides results on a single report form with side-by-side phenotypic and genotypic resistance data
• Supplements resistance results with replication capacity information to evaluate viral fitness
• Overcomes limitations associated with the use of a single method alone
• Avoids complications associated with separate samples and separate laboratories by performing both tests from one patient sample

PhenoSense GT is currently the assay of choice for determining the Optimized Background (OB) to be given with investigational agents in clinical trials.

Click here to download sample report (PDF)

Click here to download the PhenoSense GT assay process slide

Phenotypic and Genotypic HIV-1 Drug Resistance Assays Provide Complementary Information. N. Parkin et al; Journal of Acquired Immune Deficiency Syndromes, 2002, Vol. 31, No. 2, pp. 128-136

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